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. 2020 Jun 19;11:690. doi: 10.3389/fphys.2020.00690

FIGURE 5.

FIGURE 5

Female mdx carriers present mild metabolic impairments that are exacerbated with high-fat diet feeding. Female mdx carriers fed with normal chow (A–I) (N = 6–10): (A) Tissue weight relative to body weight. (B) Body weight (grams). (C,D) Glucose and insulin tolerance tests with area under the curve (AUC) insert. (E) 2-Deoxyglucose uptake with or without insulin in excised soleus muscle. (F) Immunoblot images for respective proteins. (G) Electron micrograph images of the soleus muscle with quantified mitochondrial area and cristae numbers per area of mitochondria shown bottom. Black arrow indicates mitochondrial vacuoles. (H) Complex IV activity in quadriceps muscle. (I) Mitochondrial respirometry analysis in quadriceps muscle. Female mdx carriers fed with high-fat diet (J–L) (N = 6–7): (J) Tissue weight relative to body weight. (K) Body weight during high-fat diet feeding. (L) Glucose tolerance tests with area under the curve (AUC) insert. Data presented as Mean ± SEM. *P < 0.05.