Figure 4.

An Interaction Network of Invasion Suppressors

Interactions between genes for which KD enhanced the categories “invasion,” “multilayering,” and “cell body rounding” are shown. Each circle node represents a gene. Node color indicates phenotype observed in the screen: green, invasion; blue, cell-body rounding; red, multilayering; multi-coloured nodes, genes that were hits for more than one phenotype; white, lethal; black, “linker genes,” i.e., genes that were not part of the screen, but that connect screen hit genes by one interaction; nodes with a bold outline, hub genes in this network. Lines represent interactions: cyan, genetic; orange, protein-protein; green, interolog. MCODE complexes of highly interconnected genes are outlined in black. Significantly enriched GO terms are indicated. See also Data S1.