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. 2020 Jun 19;11:584. doi: 10.3389/fphys.2020.00584

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Copyright © 2020 Mahmutovic Persson, Falk Håkansson, Örbom, Liu, von Wachenfeldt and Olsson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene expression at day 28 in samples from high- and low-responder groups. Gene expression of (A) CCL3 (MIP-1α), (B) integrin-β8, (C) TIMP1, (D) TNF-α, (E) gremlin1, (F) CTGF, (G) TGF-βIII, (H) TGF-β receptor I, (I) TGF-β receptor II, (J) α-SMA, (K) Collagen I, (L) IL-5, (M) CCL12 (MCP-5), (N) IL-10, and (O) IL-13, are all presented as mean ± standard error of the mean (SEM). All samples from the bleomycin group are related to the mean of control and normalized to the geometric mean of five different reference genes. Each presented group contains n = 3 and are only samples analyzed from the group of rats undergoing longitudinal imaging, being terminated at day 28. Significance is indicated by * when p < 0.05; p < 0.01 by ** and p < 0.001 by ***, when comparing bleomycin towards the saline control. The comparison between bleomycin-challenged groups is expressed as # when p < 0.05 and #### when p < 0.0001.