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. 2020 Jun 19;7:214. doi: 10.3389/fmed.2020.00214

Figure 1.

Figure 1

ADAM9 expression in breast clinical samples and breast cell lines. (A) ADAM9 was markedly upregulated in clinical samples of TNBC primary tumor (n = 34) compared to ER+ breast cancer primary tumor (n = 37) in NCBI GEO (GSE58135) database (PT = primary tumor); (B) ADAM9 protein expression was upregulated in MDA-MB-231 cells compared to the other non-TNBC cell lines (MCF-7, MDA-MB-361, SKBR3, and MCF-10A); (C) Western blotting showed the increased ADAM9 protein expression in MDA-MB-231 and Hs578t cell lines; (D) RT-qPCR analysis indicated upregulated ADAM9 mRNA expression in TNBC cell line; (E) TNBC cell lines showed significantly overexpressed ADAM9 mRNA compared with non-TNBC cell lines in GSE58135 dataset; (F) ADAM9 mRNA expression from CCLE showed overexpressed ADAM9 in TNBC cell lines compared with non-TNBC cell lines. (*p-value < 0.05, **p-value < 0.01, ***p-value < 0.001).