Table 3.
Select MPNST RNA expression array data (>400 genes screened)
| Reference | Comparison | Subset of increased genes | Subset of decreased genes |
|---|---|---|---|
| 48 | 16 MPNST primary vs. neurofibromas [636 chr 17 genes] | TOP2A, FKBP10, MFAP4, VMP1, AP2B1, TIMP2, MRC2, PYCR1, MYH1, SOX9 | n/a |
| 49 | 20 MPNSTs; NF1 vs. non-NF1 [8100 genes] | MBP, S100B, NCAM, L1CAM, GAP43, SOX10, CRYAB | MKI67, FGFR1, CCNB2 |
| 49 | 20 MPNSTs, EGFR+ vs. EGFR− [8100 genes] | EGFR, HSF1, MFAP, COSF1, MKI67, FGFR1, BIRC5, LMNB2 | n/a |
| 50 | 8 NF1 MPNST cell lines and 45 primary MPNST vs. normal SC [47 000 genes] | SOX9, TWIST1, TNNT1, ADA, FOXD1, RGS2, FLRT2, PLCB2, BASP1, PAIP1, TM4SF1, RGS2, ETV1, HMGA2 | SOX10, SPP1, CD59, TGFBR2, TIMP2, CDH19, GFRA2, PMP22, NGFR, GSN, LMNB2, SPARC, TRAF1, BHLHB2, ITGA6, ERBB2, L1CAM, HYAL1, TIMP3, CRYAB, CNP |
| 44 | 1 primary and 2 MPNST cultures vs. neurofibromas [539 genes] | EGFR, HSPCA, LAMP2, MALAT1, MYO10, SEC3L1, CYP1B1 | ITGA6, GSN, CRYAB, MATN, CD59, CDH19, RPL3, FOXD3, SPARC, APOD |
| 53 | 9 MPNST (mostly non-NF1) vs. 4 neurofibromas [886 genes] | BIRC5, TNC, ADA, COL6A3, COL7A1, KRT18 | IGFBP6 |
| 54 | 4 MPNST vs. 6 plexiforms [16 840 genes] | TNC, CNNB2, DNMT3A, CCND2, SEMA3A, OSF2, BIRC5, SPP1, TOP2A | TNXB, FOX01A, ITGB4, IGF1, TPSB, HSPB2, CBX7, GPR56 |
| 51 | sNF94.3 & sNF02.2 NF1 MPNST cell lines vs. normal SC [96 genes] | VEGFC, NRP1, EGFR, ANGPT1, FGFR3, FGFR2, ADAMTS1 | SPP1, PDGFA, ITG5A, SPARC |
| 55 | 11 MPNST cell lines and 6 primary MPNST vs. normal SC, but not similarly altered in neurofibromas (22 cultures and 26 primary) [47 000 genes] | EYA4, FOXE1, FZD2, PAX6, SOX11, COL4A6, SEMA6B, ZIC1, CAST1, IHPK2, DNMT3B, HMGA2, DMRT1, EPHB2, H2AFY2, HIST1H2BD, DNER | S100B, ITGB3, NGFR, ERBB2, CDKN2A, PDGFRA, PDGFB, PMP22, GSN, FYN, CRYAB, SPARC, TIMP3, MIA, PSMAL, PTPRE |
| 55 | Altered similarly in most neurofibromas also | SOX9, FGFR1, EN1, EGFR, SHC1, KIT, ROBO1, CD36, S100A4, SPRY1, TWIST1, ITGB5, TNNT2, RORA, SPRY1, SPRY4, ETS2 | CENTA1, DNMT2, GIT1, GAP43, L1CAM, MBNL2, MBP, PSD2, S100A1, TRPM3, MAF, QK1, SOX8, ITGB8, PAX3, NTRK3 |
| 55 | MPNST cell lines only vs. normal SC | BMP4, COL4A5, FBLN1, MDK, MSH6, PAX6, PDE9A, S100BP, SEC14L1, EFNB2, ZIC1, AURKA, TRGB4, HGF | ERBB2, PMP22, GSN, ITGB3, PDGFB, TLN2, ECM1, RASSF1, CRYAB, SPARC, TIMP3, FYN, CD74, CRK, RAB7 |
| 57 | 20 MPNST vs. neurofibromas [28 000 genes] | BEX1, CPA3, DLK1, CRABP1, IGFBP2, IFG2, PTK7, FGFR1, TWIST1, CCNB2, GAS1, EGFR, TPX2, CYTL1 | SOX10, MAL, CRYAB, L1CAM, ITGA2, CDH1, S100B, ERBB3, PMP22, GBP2, ITGB8, QKI, TGFBR2, TMEM23, THBS2 |
n/a, not applicable; SC, Schwann cells.