Table 1.
Comparison between sporadic and NF1-associated OPGs in children
| NF1-associated | Sporadic | |
|---|---|---|
| Age | < 6 years | < 6 years (frequently <1 year) |
| Location | Optic nerve, chiasm, and posterior optic radiations | Chiasm |
| Relation with visual pathway | Infiltration | Compression |
| Risk of progression | Around 50% | Constant |
| Spontaneous regression | Possible | No |
| Visual Acuity Impairment | More important (+++) | Less important (++) |
| Motor impairment | Less important (++) | More important (+++) |
| Histopathology | Pilocytic Astrocytoma | Pilocytic Astrocytoma, Ganglioglioma |
| Molecular alterations | NF1 loss | KIAA1549-BRAF fusion+++, Other fusions or mutations, less frequently: NTRK2, FGFR1, BRAF V600E, KRAS, RAF1, PTPN11 |