Table 4.

Adjusted Effects of Participant Factors on Estimated C_2h of First-line Tuberculosis Drugs

Drug	Predictor	Effect on C2h	95% CI	Significance (P)
Rifampicin	Dose (mg/kg of body weight)	0.21	0.07 to 0.35	.005
	Age (years)	0.11	−0.01 to 0.24	.078
	Male vs female sex	0.54	−0.45 to 1.53	.275
	Malnourished	−2.03	−3.20 to −0.87	.001
Isoniazid	Dose (in mg/kg bodyweight)	0.22	−0.06 to 0.49	.123
	Age (years)	−0.02	−0.14 to 0.10	.799
	Male vs female sex	−0.05	−1.00 to 0.90	.918
	Malnourished	−2.06	−3.19 to −0.93	.001
Pyrazinamide	Dose (mg/kg of body weight)	0.82	0.28 to 1.37	.005
	Age (years)	0.75	−0.37 to 1.87	.178
	Male vs female sex	−0.34	−9.63 to 8.94	.940
	Malnourished	−2.70	−13.86 to 8.46	.621
Ethambutol	Dose (mg/kg of body weight)	0.04	−0.04 to 0.14	.291
	Age (years)	0.08	−0.04–0.21	.186
	Male vs female sex	0.42	−0.51 to 1.36	.355
	Malnourished	−0.80	−1.93 to 0.34	.159

Abbreviations: C_2h, peak drug concentration; CI, confidence interval.