Fig. 1. Inhibitory effects of 70% ethanolic extract of Gardenia jasminoides (GJEtOH) on ORAI1 current (IORAI1) in human STIM1 and ORAI1 co-transfected HEK293T cells.
(A) Representative chart trace recordings of IORAI1 and inhibition of IORAI1 activity by 0.1 and 0.3 mg/ml GJEtOH and 10 μM BTP2. (B) Related current (I)-voltage (V) relationship graph at steady-state IORAI1 (1), 0.1 (2), 0.3 (3) mg/ml GJEtOH and 10 μM BTP2 (4). (C) Graph shows inhibition of IORAI1 using 0.03, 0.1, and 0.3 mg/ml GJEtOH and 10 μM BTP2, compared with normalized currents at –120 mV (n = 11). ****p < 0.0001 vs. control.