Fig. 6. Concentration-dependent inhibitory effects of genipin on ORAI1 current (IORAI1) in STIM1 and ORAI1 co-transfected HEK293T cells.
(A) Normalized columnar analysis of the effects of the nine chemical constituents of 70% ethanolic extract of Gardenia jasminoides (GJEtOH) on IORAI1 (n = 6). **p < 0.01, ***p < 0.001 and ****p < 0.0001 vs. the control. DMSO, dimethyl sulfoxide; ChlA, chlorogenic acid; GnP, genipin; GeS, geniposide; GeA, geniposidic acid; Ru, rutin; Cr, crocin; Cr2, crocin II; CrA, croceic acid. (B) Normalized histograms of IORAI1 inhibition by 10, 30, 100, and 300 μM genipin (n = 12). ****p < 0.0001 vs. the control.