Figure 6.

Lack of effect of spinal ERα⁺ neuron ablation in models of persistent pain. (a, b) One and 7 days after spared nerve injury (SNI), mechanical thresholds were tested in male (a) and female (b) ERα‐Cre mice and in their WT littermate controls. There was no significant difference between groups at either time point. (c, d) Three days after intraplantar injection of Complete Freund's Adjuvant, thresholds were tested in ERα‐Cre mice and WT littermate controls. Males and females were pooled due to low numbers. There was no significant difference between groups in mechanical allodynia (c) or thermal hyperalgesia (d). Data are presented as mean ± SEM