Fig. 4.

Computational modeling. (a) Overview of whole L-type calcium current model under voltage-clamp protocol. LTCC current from the control (black), DCM (blue) and ICM (red) models. Currents were normalized and plotted on the same graph to compare their decay rates. The three rows represent the whole cell LTCC current (first row), the TT component (second row) or the crest component (third row). (b) Comparation of membrane voltage and L-type Calcium current traces. For the ICM model, EADs were obtained when the LTCCs in the TTs were phosphorylated by PKA (top row, left), but not when PKA activity was blocked (top row, right). Similarly, arrhythmogenic triggers developed in the DCM model when LTCCs from the crest were phosphorylated by CaMKII (bottom row, left), and not when CaMKII activity was blocked (bottom row, right).