Table II. Summary of main findings regarding the alterations in the endocannabinoid system elements in endometrial and placental diseases.

Pathology	Altered ECS	Tissue	Study
Endometriosis	AEA	↑Plasma	(Sanchez et al., 2016)
	2-AG	↑Plasma	(Sanchez et al., 2016)
	CB1	↓Endometrium	(Sanchez et al., 2016)
		↑Myometrium	(Shen et al., 2019)
	CB2	↑Myometrium	(Shen et al., 2019)
Ectopic pregnancy	AEA	↑Fallopian tubes	(Horne et al., 2008)
		↑Plasma	(Gebeh et al., 2013)
	OEA	↑Plasma	(Gebeh et al., 2013)
	PEA	↑Plasma	(Gebeh et al., 2013)
	CB1	↓Decidua and Fallopian tubes	(Horne et al., 2008)
	FAAH	↓Fallopian tubes	(Gebeh et al., 2012)
		↓Plasma	(Gebeh et al., 2013)
Miscarriage	AEA	↑Plasma	(Maccarrone et al., 2002)
		↑Uterine NK cells	(Fonseca et al., 2019)
	CB1	↑1st Trimester placenta	(Trabucco et al., 2009)
	NAPE-PLD	↑1st Trimester placenta	(Trabucco et al., 2009)
	FAAH	↓Peripheral lymphocytes	(Maccarrone et al., 2000)
		↓1st Trimester placenta	(Maccarrone et al., 2002)
		↓1st Trimester placenta	(Trabucco et al., 2009)
Pre-eclampsia	AEA	↓Plasma	(Molvarec et al., 2015)
	CB1	↑Placenta	(Fugedi et al., 2014)
	NAPE-PLD	↑Placenta	(Fugedi et al., 2014)
		↓Placenta	(Aban et al., 2013)
	FAAH	↓Placenta	(Fugedi et al., 2014)
		↑Placenta	(Aban et al., 2013)
Endometrial cancer	AEA	↑Endometrium	(Ayakannu et al., 2019)
		↑Endometrium	(Schmid et al., 2002)
		↑Plasma	(Ayakannu et al., 2014)
	2-AG	↑Endometrium	(Guida et al., 2010)
	CB1	↓Endometrium	(Ayakannu et al., 2014)
	CB2	↑Endometrium	(Guida et al., 2010)
		↓Endometrium	(Ayakannu et al., 2014)
	MAGL	↓Endometrium	(Guida et al., 2010)

NK, natural killer; OEA, N-oleoylethanolamine; PEA, N-palmitoylethanolamine.