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. 2020 Jun 19;8:449. doi: 10.3389/fcell.2020.00449

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Copyright © 2020 Norkett, Lesept and Kittler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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mutDISC1 impairs positioning of mitochondria at the presynapse. (A) Confocal images showing colocalization of mitochondria with presynaptic sites labeled with synaptophysin GFP (control) or upon expression of the mutDISC1. (B) Percentage of synapses colocalizing with mitochondria is decreased upon expression of mutDISC1 (N = 11 ctrl and 11 mutDISC1-expressing neurons, p = 0.028). (C) Mitochondrial area is decreased upon expression of DISC1 4 bp deletion (p = 0.017). (D) Mitochondrial density is unaffected by expression of mutDISC1 (p = 0.508). Synaptic area (E) and density (F) are unchanged by expression of mutDISC1 (p = 0.933 and p = 0.392, respectively).