Table 2.

The Gene Ontology (GO) functional terms and pathways enriched for the 53 hub genes.

Category	Description	Count	p adjust
Biological process	GO:0003158~endothelium development	7	1.69E − 08
	GO:0001570~vasculogenesis	6	2.66E − 08
	GO:0048010~vascular endothelial growth factor receptor signaling pathway	6	7.30E − 08
	GO:0030947~regulation of vascular endothelial growth factor receptor signaling pathway	4	1.08E − 06
	GO:0045602~negative regulation of endothelial cell differentiation	3	2.72E − 06
	GO:0045601~regulation of endothelial cell differentiation	4	3.21E − 06
	GO:0045446~endothelial cell differentiation	5	6.41E − 06
	GO:0061298~retina vasculature development in camera-type eye	3	1.00E − 05
	GO:0045765~regulation of angiogenesis	7	2.96E − 05
	GO:0090287~regulation of cellular response to growth factor stimulus	6	5.17E − 05
	GO:1901342~regulation of vasculature development	7	5.58E − 05
	GO:0001935~endothelial cell proliferation	5	8.52E − 05
	GO:0045766~positive regulation of angiogenesis	5	1.08E − 04
	GO:0031589~cell-substrate adhesion	6	1.40E − 04
	GO:0038084~vascular endothelial growth factor signaling pathway	3	1.45E − 04
Cell component	GO:0043235~receptor complex	8	7.12E − 04
	GO:0005911~cell-cell junction	7	6.60E − 03
Molecular function	GO:0019199~transmembrane receptor protein kinase activity	5	2.65E − 04
	GO:0004714~transmembrane receptor protein tyrosine kinase activity	4	1.15E − 03
	GO:0019838~growth factor binding	5	1.15E − 03
	GO:0070888~E-box binding	3	9.27E − 03
Pathway	hsa04510~focal adhesion	4	2.06E − 03
	hsa04015~Rap1 signaling pathway	4	2.34E − 03
	hsa04670~leukocyte transendothelial migration	3	3.64E − 03