Table 1.

Summary of models highlighted in the main text

Scale	Reference	Type of model	Cell types included
			T cells	NK cells	B cells	Macrophages	DCs	Tumor cells
Single cell	Arulraj et al. (2018)	ODEs	Effector T cells
	Mesecke et al. (2014)	ODEs		•
	Ziegler et al. (2019)	ODEs			•
	Sung et al. (2014)	ODEs				•
Multicellular	Hoffmann et al. (2018)	ODEs		•				•
	Robertson‐Tessi et al. (2012)	ODEs	CTLs, Th, Treg				•	•
	Robertson‐Tessi et al. (2015)	ODEs	CTLs, Th, Treg				•	•
	Arabameri et al. (2019)	ODEs	CTLs, Th, Treg				•	•
	Li et al. (2015)	ODEs	CTLs	•			•	•
	Mahasa et al. (2016)	ODEs	CTLs	•				•
Spatial	Liao et al. (2014a)	PDEs	CTLs					•
	Liao et al. (2014b)	PDEs	CTLs					•
	Gong et al. (2017)	ABM	CTLs					•
	Kather et al. (2017)	ABM	CTLs					•
	Mahlbacher et al. (2018)	PDEs				•		•
	El‐Kenawi et al. (2019)	ABM, PDEs				•		•
Intracellular signaling‐cellular response	Prokopiou et al. (2014)	ABM, PDEs	Naïve T cells					•
	Gao et al. (2016)	ABM, PDEs	Naïve T cells					•
	Girel et al. (2019)	ABM, PDEs	Naïve T cells					•
Multiple tissues	Kim et al. (2018)	ODEs	CTLs				•	•
Systems pharmacology	Milberg et al. (2019)	ODEs	Naïve, Primed, Treg, Effector					•