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. 2020 Jan 27;107(6):941–952. doi: 10.1002/JLB.3MA1219-398R

Figure 2.

Figure 2

RIP1 kinase inhibition reduces liver, but not esophageal or intestinal, inflammatory infiltrates in Cpdm mice. (A–C) Histologic sections of liver (A), esophagus (B), and colon (C) demonstrated inflammatory infiltrates in Cpdm mice, although these infiltrates are relatively minimal in the colon. (D) Histologic scores of hepatic, esophageal, and colonic inflammation demonstrate abatement of inflammation in the liver, but not in the esophagus or colon, in Cpdm mice following treatment with GNE684 (G684). Asterisks indicate P = 0.0054. Bars depict mean with sd, P‐values were determined by Mann‐Whitney test. Wild‐type, N = 18; GNE684 treated Cpdm, N = 8; vehicle treated Cpdm, N = 8