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. 2019 Dec 31;183(4):208–216. doi: 10.1002/ajmg.b.32777

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© 2019 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Enrichment results for the PGC‐OCD (black) and the OCD + compulsion symptoms meta‐analysis (orange). Enrichment of tissue‐specific differentially expressed genes (DEGs) was determined using the hypergeometric test. The y‐axis shows the Bonferroni corrected significance of the test as –log 10(p). The dashed line indicates the significance threshold (p = .05). Significance strongly increased for some brain tissues (over 1 point increase for ACC, amygdala, hippocampus and frontal cortex), and decreased for others (over 1 point decrease for cortex, substantia nigra) [Color figure can be viewed at wileyonlinelibrary.com]