Figure 4.

(a) Mean change in eosinophil count from baseline to week 16 (SOLO 1 & 2) and week 52 (CHRONOS). (b) Absolute eosinophil count. A close‐up view of the box‐and‐whisker plots is depicted below. White horizontal lines indicate medians. X depicts mean values. Top and bottom of each box represent Q3 and Q2, respectively. Upper and lower vertical bars represent Q4 and Q1, respectively; horizontal segments on each end of the vertical bars represent minimum and maximum values. Outliers for eosinophil counts 1·501–5·0 × 10⁹ L⁻¹ and > 5·0 × 10⁹ L⁻¹ are presented as light red and dark red dots, respectively. (c) Proportion of patients with eosinophilia grades 1–3; patient numbers are provided in Table 3. Eosinophilia grade scale follows the guidance provided by the U.S. Food and Drug Administration.37 BL, baseline; Q, quartile; qw, once weekly; q2w, every 2 weeks; TCS, topical corticosteroids; Wk, week.