Table 2.
| Study week | Neutropenia grade | SOLO 1 & 2, n (%)c | CHRONOS, n (%) | ||||
|---|---|---|---|---|---|---|---|
| Placebo qw (n = 456) | Dupilumab 300 mg q2w (n = 465) | Dupilumab 300 mg qw (n = 455) | Placebo qw + TCS (n = 315) | Dupilumab 300 mg q2w + TCS (n = 110) | Dupilumab 300 mg qw + TCS (n = 315) | ||
| 0 | 1 | 11 (2·4) | 8 (1·7) | 14 (3·1) | 3 (1·0) | 1 (0·9) | 5 (1·6) |
| 2 | 4 (0·9) | 2 (0·4) | 0 | 2 (0·6) | 0 | 1 (0·3) | |
| 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 4 | 1 | 7 (1·5) | 22 (4·7) | 28 (6·2) | 5 (1·6) | 5 (4·5) | 10 (3·2) |
| 2 | 2 (0·4) | 4 (0·9) | 2 (0·4) | 1 (0·3) | 1 (0·9) | 4 (1·3) | |
| 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 8 | 1 | 12 (2·6) | 22 (4·7) | 23 (5·1) | 4 (1·3) | 3 (2·7) | 11 (3·5) |
| 2 | 4 (0·9) | 1 (0·2) | 2 (0·4) | 1 (0·3) | 0 | 1 (0·3) | |
| 3 | 0 | 0 | 1 (0·2) | 0 | 0 | 0 | |
| 12 | 1 | 11 (2·4) | 22 (4·7) | 24 (5·3) | 2 (0·6) | 1 (0·9) | 11 (3·5) |
| 2 | 0 | 4 (0·9) | 1 (0·2) | 1 (0·3) | 1 (0·9) | 1 (0·3) | |
| 3 | 1 (0·2) | 0 | 0 | 0 | 0 | 1 (0·3) | |
| 16 | 1 | 9 (2·0) | 16 (3·4) | 15 (3·3) | 4 (1·3) | 1 (0·9) | 6 (1·9) |
| 2 | 2 (0·4) | 3 (0·6) | 5 (1·1) | 0 | 0 | 1 (0·3) | |
| 3 | 0 | 1 (0·2) | 0 | 0 | 0 | 0 | |
| 20 | 1 | – | – | – | 9 (2·9) | 2 (1·8) | 3 (1·0) |
| 2 | – | – | – | 1 (0·3) | 0 | 1 (0·3) | |
| 3 | – | – | – | 0 | 0 | 0 | |
| 28 | 1 | – | – | – | 4 (1·3) | 3 (2·7) | 11 (3·5) |
| 2 | – | – | – | 0 | 0 | 4 (1·3) | |
| 3 | – | – | – | 0 | 0 | 0 | |
| 36 | 1 | – | – | – | 5 (1·6) | 8 (7·3) | 8 (2·5) |
| 2 | – | – | – | 0 | 0 | 3 (1·0) | |
| 3 | – | – | – | 0 | 0 | 0 | |
| 44 | 1 | – | – | – | 8 (2·5) | 3 (2·7) | 8 (2·5) |
| 2 | – | – | – | 0 | 2 (1·8) | 3 (1·0) | |
| 3 | – | – | – | 0 | 0 | 0 | |
| 52 | 1 | – | – | – | 2 (0·6) | 4 (3·6) | 8 (2·5) |
| 2 | – | – | – | 1 (0·3) | 0 | 1 (0·3) | |
| 3 | – | – | – | 0 | 0 | 1 (0·3) | |
a
Neutropenia grade scale follows the guidance provided by the U.S. Food and Drug Administration37 grade 1: neutrophil counts of 1·5–2·0 × 109 L−1; grade 2: 1·0–1·499 × 109 L−1; grade 3: 0·5–0·999 × 109 L−1; grade 4: < 0·5 × 109 L−1. bNo patients in SOLO 1 & 2 and CHRONOS reported grade 4 neutropenia.
Post‐16‐week data were not collected for SOLO; qw, once weekly; q2w, every 2 weeks; TCS, topical corticosteroids.