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. 2019 Oct 10;30(3):446–464. doi: 10.1111/bpa.12787

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© 2019 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Nodules in Pdgfb^ret/ret and Slc20a2^−/− are confirmed to be vessel associated. A. Small vessel association of calcifications in Pdgfb^ret/ret and Slc20a2 ^−/− mice verified by co‐immunolabeling with APP, CD13 and CD31 on vibratome sections. Scale bars, 50 µm. B. Volumetric 3D rendering of a calcification in Pdgfb^ret/ret (red) attached to a CD31‐positive vessel (purple). C. Percentage of calcifications associated with vessels in deeper brain regions in 2‐ (n = 4) and 12‐month‐old (n = 3) Pdgfb^ret/ret mice.