Figure 8.

Effects of GPS-mediated Nrf2 on Ty-induced hepatic steatosis and oxidative stress. GPS (80 mg/kg) was intraperitoneal injection to WT and Nrf2^−/− mice for 1 h; after that, injected with Ty (500 mg/kg) for 12 h. (a–h) TC, TG, ALT, AST, and SOD in the serum and AOC, GSH, and MDA in the liver were assayed using assay kits. (i) Representative microphotograph of Oil Red O staining of liver tissues (magnification ×100, scale bar = 100 μm). All data are presented as mean ± SD (n = 3, number of mice in each group). ^#p < 0.05 and ^##p < 0.01 vs. control group; ^∗p < 0.05 and ^∗∗p < 0.01 vs. Ty-stimulated group group.