Figure 16.

Structural comparison of the flavin cofactor in flavin-dependent monooxygenases (FMO)s. Some FMOs catalyze oxidation reactions and others catalyze halogenation reactions. PhqK (red), PqsL FMO, PDB: 6fho (orange), MalA’ halogenase, PDB: 5wgr (yellow), PltA halogenase, PDB: 5dbj (green), and decarboxylative hydroxylase, PDB: 5eow (blue). The discrete conformations captured in these structures indicate the ancestral relationship of these flavin-dependent enzymes. Model generated using PyMol Molecular Graphics System.