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. 2020 May 20;7(6):924–931. doi: 10.1002/acn3.51056

Table 3.

Clinical characteristics, PLM and ferritin levels in controls and NT1 patients.

Variable

Controls

N = 38

NT1 patients

N = 66

Model 0 Model 1
n % n % P P
Gender, women 26 68.42 22 33.33 0.0008  
Age, years 1 22.50 (12.00; 61.00) 38.50 (14.00; 81.00) 0.0009  
BMI, kg/m2 1 20.77 (16.45; 35.19) 26.12 (18.73; 37.11) <0.0001  
ESS score 1 15.00 (5.00 ;23.00) 20.00 (6.00 ;24.00) 0.001  
Duration of evolution of NT1, years 1 10 (1.00; 69.00)  
PLM indexes
Index PLMS, /h 1 0.17 (0.00; 14.20) 4.10 (0.00; 161.90) 0.005  
Index PLMS ≥15/h 0 0 18 27.27 NA  
Index PLMS associated with MA, /h 1 0.00 (0.00; 3.30) 1.30 (0.00; 50.70) 0.02  
Index of PLMS associated with MA ≥15/h 0 0 2 3.17 NA  
Index PLM wake, /h 1 1.50 (0.00; 62.00) 11.55 (0.00; 105.60) 0.56  
Index PLM wake ≥15/h 7 18.42 25 39.06 0.87  
Ferritin levels
Ser‐Ferr, ng/mL 1 51.50 (6.00; 418.00) 100.00 (12.00; 500.00) 0.009  
Ser‐Ferr ≤50 ng/mL 15 50.00 12 19.05 0.003  
Ser‐Ferr ≤75 ng/mL 18 60.00 21 33.33 0.02  
CSF‐Ferr, ng/mL 1 4.87 (2.09; 11.98) 6.64 (3.00; 14.89) 0.0008 0.09
CSF‐Ferr, ng/mL 2  
<4.66 18 47.37 15 22.73 0.008 0.26
[4.66–6.89] 14 36.84 22 33.33    
≥6.89 6 15.79 29 43.94    

Model 0: crude association. Model 1: adjustment for age, gender, and serum ferritin levels. BMI, body mass index; CSF, cerebrospinal fluid; CSF‐Ferr, CSF ferritin levels; ESS, Epworth sleepiness scale; MA, microarousal; NT1, narcolepsy type 1; PLM, periodic leg movements; PLMS, periodic leg movements during sleep; RLS, restless legs syndrome; Ser‐Ferr, serum ferritin levels; NA, test not applicable.

1

Continuous variables are expressed as median (minimal value; maximal value).

2

Tertiles of the whole sample (n = 104).