Table 4.

Correlations between serum markers and Expanded Disability Status Scale scores according to age.

Three age groups	MS				NMOSD				p † (MS vs. NMOSD)
	Pearson r	n	P ‡		Pearson r	n	P ‡		Uncorrected	Corrected (Bonferroni)
			Uncorrected	Corrected (Bonferroni)			Uncorrected	Corrected (Bonferroni)
Log NfL
≤44	0.422**	56			‐0.182	13			0.066	0.198
45−54	0.301	32	0.546	>0.999	0.103	20	0.471	>0.999	0.498	>0.999
≥55	0.327	25	0.663	>0.999	0.594**	28	0.034	0.068	0.590	>0.999
Log GFAP
≤44	0.196	56			0.754**	12			0.030	0.090
45−54	0.396*	31	0.346	0.692	0.530*	19	0.347	0.694	0.585	>0.999
≥55	0.302	25	0.656	>0.999	0.075	25	0.022	0.044	0.433	>0.999

EDSS, Expanded Disability Severity Scale; GFAP, glial fibrillary acidic protein; MS, multiple sclerosis; NfL, neurofilament light chain; NMOSD, neuromyelitis optica spectrum disorders.

Significant correlations with EDSS score,

^* P < 0.05,

^** P < 0.01,

^*** P < 0.001;

^† P value for differences in correlation coefficients between the MS and NMOSD groups;

^‡ P value for differences in correlation coefficients between the age groups within the disease group (vs. the reference [the youngest] group).