TABLE 2.

The biological processes regulated by the molecular targets of S1P in Homo sapiens.

Gene set	Description	Size	Expect	Ratio	P-value	FDR
GO:0003376	Sphingosine-1-phosphate receptor signaling pathway	10	0.053402	131.08	1.1546e-14	1.0497e-10
GO:0090520	Sphingolipid mediated signaling pathway	11	0.058742	119.16	3.1530e-14	1.4332e-10
GO:0007200	Phospholipase C-activating G protein-coupled receptor signaling pathway	96	0.51266	23.407	1.0836e-13	3.2836e-10
GO:0050801	Ion homeostasis	776	4.1440	6.0328	1.6986e-13	3.8606e-10
GO:0007186	G protein-coupled receptor signaling pathway	1290	6.8889	4.5000	2.6357e-13	4.5957e-10
GO:0048878	Chemical homeostasis	1119	5.9757	4.8530	3.0331e-13	4.5957e-10
GO:0051482	Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	31	0.16555	48.325	3.4222e-12	4.4444e-9
GO:0007204	Positive regulation of cytosolic calcium ion concentration	301	1.6074	9.9539	4.6408e-12	5.2737e-9
GO:0006874	Cellular calcium ion homeostasis	439	2.3444	7.6780	1.4333e-11	1.4478e-8