TABLE 5.
Top 15 respiratory diseases associated with the molecular targets of S1P.
| Disease full name | Relevance (p-value) | Number of associated targets | Therapeutic area | Highest associated targets (max 10) |
| Lung disease | 6.00E-42 | 82 | Respiratory system disease | KDR TYMS CHRM3 MMP8 NR3C1 CHRM1 AKT1 CA4 ACE MMP2… |
| Respiratory system disease | 2.00E-39 | 84 | Respiratory system disease | KDR TYMS CHRM3 MMP8 HRH1 NR3C1 CHRM1 AKT1 CA4 MMP2… |
| Respiratory system neoplasm | 2.00E-38 | 77 | Neoplasm, respiratory system disease | KDR TYMS NR3C1 AKT1 MMP2 DHFR FDPS GRB2 MMP8 MMP12… |
| Bronchial disease | 2.00E-38 | 58 | Respiratory system disease | NR3C1 CYSLTR1 HRH1 CHRM1 CHRM3 DHFR GSTM1 MAPK14 CASP1 S1PR2… |
| Lung carcinoma | 5.00E-38 | 78 | Neoplasm, respiratory system disease | KDR TYMS NR3C1 AKT1 MMP2 DHFR FDPS GRB2 MMP12 IDO1… |
| Asthma | 1.00E-35 | 55 | Respiratory system disease | NR3C1 CYSLTR1 HRH1 CHRM3 CHRM1 DHFR GSTM1 MAPK14 CASP1 S1PR2… |
| Interstitial lung disease | 3.00E-32 | 43 | Respiratory system disease | NR3C1 KDR MMP8 CTSK EZH2 SOAT1 CYSLTR1 SIRT1 CASP3 MMP12… |
| Chronic obstructive pulmonary disease | 8.00E-32 | 48 | Respiratory system disease | CHRM3 MMP8 ACE NR3C1 CA1 CHRM1 CA12 CA4 CA2 MMP12… |
| Rare genetic respiratory disease | 3.00E-31 | 44 | Genetic disorder, respiratory system disease | MMP8 FDPS NR3C1 CHRM3 SIRT1 PRSS1 EZH2 CTSK HRH1 KISS1R… |
| Idiopathic pulmonary fibrosis | 2.00E-29 | 39 | Neoplasm, respiratory system disease | NR3C1 KDR MMP8 CTSK EZH2 SOAT1 CASP3 MMP2 ANPEP TYMS… |
| Pulmonary fibrosis | 7.00E-29 | 37 | Neoplasm, respiratory system disease | NR3C1 KDR MMP8 CTSK EZH2 SOAT1 CASP3 MMP12 ANPEP MMP2… |
| Acute lung injury | 9.00E-28 | 32 | Respiratory system disease | MAPK14 MMP8 MMP2 GSK3B IDO1 S1PR1 SIRT1 CASP1 CASP3 SOAT1… |
| Pneumonia | 2.00E-27 | 37 | Infectious disease, respiratory system disease | MMP8 NR3C1 CHRM3 CHRM1 MMP12 ACE DHFR SOAT1 F2 MMP2… |
| Whooping cough | 3.00E-27 | 32 | Infectious disease, respiratory system disease | CASP1 CASP3 AKT1 CA1 S1PR4 S1PR1 MAPK1 HRH1 MMP2 TRPV1… |
| Non-small cell lung adenocarcinoma | 3.00E-26 | 42 | Neoplasm, respiratory system disease | SIRT1 EZH2 CASR GSK3B TYMS MMP2 IDO1 KDR CASP3 CA9… |