Figure 3.

Cytoskeletal motors and adaptors in the polarized and local traffic of dendritic proteins. Schematic shows the microtubule (kinesin, dynein) and actin motors (myosins, myo) involved in the retrieval of somatodendritic proteins from the axon initial segment and transport from the cell body to dendrites. In addition, the myosin motors that drive membrane traffic in dendritic spines are shown. Kinesin motors are summarized under their respective families (e.g. kinesin-1) and the adaptor/scaffold proteins that mediate interaction with dendritic cargo are provided in parentheses.