Figure 1.
IL‐13 induces BHR and mixed inflammatory cell airway inflammation. A, Bronchial hyperresponsiveness to methacholine challenge of control and Ccsp/Il13 transgenic mice on DOX for 7 d. Resistance (R: cmH2O.s/mL) at methacholine concentrations from 0 to 10 mg/mL in phosphate‐buffered saline (PBS). Data are shown as mean ± SEM. B, Differential cell counts of BALF from Ccsp/Il13 and control mice (M∅ = macrophages; Ly = lymphocytes; Neu = neutrophils; and Eo = eosinophils). Box plots show medians and 25th to 75th percentiles, and whiskers represent minimum and maximum values; all data points are shown. N = 6 mice per group. Data are representative of three independent experiments. Statistical analysis was performed using two‐way ANOVA with Tukey's multiple comparison test. **P < .01