Figure 6.

The EGFR inhibitor AG1478 blocks the pro‐neutrophilic responses caused by IL‐13 expression in vivo. Ccsp/Il13 mice were fed DOX for 7 d to induce IL‐13 and treated with dexamethasone (light grey bars), AG1478 (dark grey bars), dexamethasone + AG1478 (hatched bars) or vehicle control (white bars). A, Airway resistance in response to increasing concentrations of methacholine (0‐10 mg/mL). B and D, Differential inflammatory cell counts in BALF for neutrophils and eosinophils, respectively. C and E, CXCL1 or CCL11 protein expression, respectively, measured by ELISA in whole‐lung lobe lysates; data are shown as mean + SD. N = 6 per group from two independent experiments. Statistical analysis was performed using one‐way ANOVA. *P < .05, **P < .01