Skip to main content
. 2020 Mar 18;41(7):1250–1262. doi: 10.1002/humu.24010

Figure 3.

Figure 3

Residual activity of ALPL variants (mutant plasmids and 50:50 WT:mutant plasmid cotransfections) relative to WT (a) and fraction of residual activity of ALPL variants relative to WT (b) categorized by protein domain location. Each mutant's cDNA is listed relative to canonical RefSeq transcript NM_000478.6, and is colored according to the protein domain in which it appears, based on the descriptions and positions referenced in Silvent et al. (2014). p Values from pairwise Kruskal–Wallis nonparametric tests are added on top of each pair of groups if they are below significance threshold. cDNA, complementary deoxyribonucleic acid; TNSALP, tissue‐nonspecific alkaline phosphatase; WT, wild‐type