Figure 8.

Calculated HL angle variances displaying different frequency ranges. A, ABangle HL angle distributions for the scFv MD simulation, complex MD simulation, and the complex NOE restraints simulation. B, Angle variations of the domain movements occurring in the timescale slower than 10 ns. C, Angle variations capturing the domain movements occurring in the 0.1‐ns and 10‐ns timescale. D, Angle domain variations occurring faster than 0.1 ns. MD, molecular dynamics; scFv, single‐chain variable fragment antibody [Color figure can be viewed at wileyonlinelibrary.com]