Table 9.
Overview of head‐to‐head trials comparing SCIT and SLIT in pediatric allergic asthma and allergic rhinitis
| Study | Study design | Patients (n) | Age (Mean:SD) | Allergen extract | Allergen extract, manufacturer | Cumulative 1 year dose | Duration | Clinical Results for Allergic Asthma | Efficacy on asthma symptom and medication use | Clinical Results for AR | Efficacy on AR symptom and medication use |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Eifan AO et al 29,30 | RCT, no placebo |
16 SCIT 16 SLIT 16 Control |
SCIT (7.0 ± 1.8) SLIT (6.5 ± 1.6) Control (7.6 ± 2.0) |
Der p, Der f 1 : 1 mixture |
SLIT; drops, ALK‐ABELLO SCIT; ALUTARD SQ, ALK‐ABELLO |
SLIT; 73 876.8 STU SCIT; 1131540 SQ‐U |
3 Year | Both SCIT and SLIT leads to reduction in asthma symptoms, medication usage, nasal and skin reactivity with sustained long term clinical improvement. | SCIT=SLIT>control |
SCIT leads to reduction in rhinitis symptoms. Both SCIT and SLIT leads to reduction in medication usage when compared to control group |
SCIT>SLIT>control for ARSS SCIT=SLIT for ARMS |
| Yukselen A31 | RCT, double‐dummy, placebo |
10 SCIT 10 SLIT 10 Placebo |
SCIT (10.9 ± 3.2) SLIT (9.2 ± 3.4) Placebo (10.1 ± 2.7) |
Der p, Der f 1 : 1 mixture |
SLIT drops (NovoHelisen Oral, Allergopharma) SCIT (NovoHelisen Depot, Allergopharma) |
SLIT; 173,733 TU SCIT; 43,770 TU |
1 Year | Both SCIT and SLIT leads to reduction in asthma symptoms, medication usage when compared to baseline. SCIT was more effective in reducing asthma symptoms compared to controls. | SCIT>SLIT>placebo |
SCIT leads to reduction in allergic rhinitis and medication requirement compared to placebo. SLIT more effective in reducing allergic rhinitis and medication requirement compared to placebo. |
SCIT>SLIT>placebo |
| Keles S et al32 | RCT, no placebo |
11 SCIT 13 SLIT 14 SCITPlusSLIT 12 Control |
SCIT (7.1 ± 1.8) SLIT (8.6 ± 2.1) SCITPlusSLIT (8.2 ± 1.4) Control (7.9 ± 2.8) |
Der p, Der f 1 : 1 mixture |
SLIT; drops, ALK‐ABELLO SCIT; ALUTARD SQ, ALK‐ABELLO |
SLIT;27150.7 STU SCIT; 1231540 SQ – U SCITPlusSLIT; 331540 SQ‐U and 21600 STU |
1.5 Years | Both SCIT and SLIT leads to reduction in asthma symptoms, medication usage, nasal and skin reactivity. Similar effect between SCITPlusSLIT regime and SCIT only. |
SCITPlusSLIT=SCIT SCIT>SLIT>control |
SCITPlusSLIT reduces rhinitis symptoms SCIT only and SCITPlusSLIT reduces medicine requirement when compared to control |
SCITPlusSLIT >SCIT SCIT=SLIT=control for AR symptoms. SCITPlusSLIT=SCIT>SLIT>control for AR medication requirement |
ARMS: Allergic Rhinitis Medication Score; ARSS: Allergic Rhinitis Symptom Score; Der f: Dermatophagoides farinae; Der p: Dermatophagoides pteronyssinus; RCT: randomized controlled study; SCIT: subcutaneous immunotherapy; SLIT: sublingual immunotherapy.