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. 2020 Feb 11;153(6):e14963. doi: 10.1111/jnc.14963

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© 2020 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Schematic of the experimental design. (a) miRNA‐9‐5p detection in rats. (b) Behavioral assessment. (c) BBB assessment in vivo. (d) Target gene validation. (e) BBB assessment in vitro. (f) mechanism of miRNA‐9‐5p on BMECs. BBB: blood–brain barrier; BMECs: Brain microvascular endothelial cells; CCI: control cortex injury; ELISA: enzyme‐linked immunosorbent assay; mNSS: modified neurological severity score; OGD: oxygen glucose deprivation; PCR: polymerase chain reaction. (n: number of rats in each group or number of independent cell culture preparations in each group;)