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Serum concentrations of metformin and lactate above and below 2.5 mg/L during 4 months of administration of metformin to people with type 2 diabetes and chronic kidney disease (CKD). Total daily metformin dosages differed between patients with CKD 3A (1500 mg), CKD 3B (1000 mg) and CKD 4 (500 mg); see text. Drawn from data presented in reference34
