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. 2019 Nov 4;75(5):1121–1132. doi: 10.1111/all.14073

Figure 5.

Figure 5

Sublingual immunotherapy (SLIT) increases frequency of unique IgG2 transcripts. A, Schematics of the human IGH locus depicting the positioning of the constant gene regions relative to the rearranged VDJ exon. B, Somatic hypermutation frequencies of unique IgG transcripts obtained from 5 patients before (2014) and after SLIT (2017) and grouped per IgG subclass. C, Relative isotype distribution of unique IgG transcripts. Central number indicates total unique IgG sequences identified. Significance was determined by chi‐squared test; **P = .0011