. 2019 Oct 23;24(3):248–257. doi: 10.1111/1744-9987.13434

Table 1.

Comparison of calcimimetics

	Evocalcet	Cinacalcet 38	Etelcalcetide 38
Molecular formula	C₂₄H₂₆N₂O₂	C₂₂H₂₃F₃N	C₃₈H₇₃N₂₁O₁₀S₂
Molecular weight (Da)	374	394	1048
Mode of action at CaR	Allosteric modulator	Allosteric modulator	Allosteric modulator and direct agonist
Location of interaction with CaR	Transmembrane domain	Transmembrane domain	Extracellular domain
Mode of administration	Daily, oral	Daily, oral	Three times weekly, intravenously at the end of hemodialysis session

CaR, calcium‐sensing receptor.