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(a) Overall structure of the M. tuberculosis RNAP complex with rifampin and DNA/RNA. The protein and DNA/RNA are shown as cartoons, and the binding pocket is shown as a surface representation. Rifampin is shown as pink sticks. (b) The mutated residues analyzed in this study are labeled. S456 and D441 are shown as yellow sticks. (c) Chemical structure of rifampin.
