TABLE 1.
Group and animal | Vegetation size (cm) |
Vegetation weight at sacrifice (g) | Vegetation MRSA counts at sacrifice (log10 CFU/g) | |||
---|---|---|---|---|---|---|
Baseline (24 h postinfection) | 4 h postexebacase | 24 h postexebacase | 96 h postexebacase | |||
Untreated control | ||||||
1 | 0.45 | 0.49 | NDa | ND | 0.12 | 8.52 |
2 | 0.61 | 0.64 | ND | ND | 0.14 | 8.71 |
3 | 0.56 | 0.66 | ND | ND | 0.32 | 8.54 |
4 | 0.72 | 0.76 | ND | ND | 0.26 | 8.87 |
5 | 0.48 | 0.60 | ND | ND | 0.24 | 9.00 |
Mean (±SD) | 0.56 ± 0.21 | 0.63 ± 0.08 | 0.22 ± 0.08 | 8.73 ± 0.21 | ||
Daptomycin alone | ||||||
1 | 0.64 | 0.52 | 0.60 | 0.70 | 0.47 | 5.28 |
2 | 0.46 | 0.43 | 0.48 | 0.57 | 0.36 | 5.49 |
3 | 0.47 | 0.63 | 0.54 | 0.54 | 0.29 | 5.88 |
4 | 0.50 | 0.48 | 0.57 | 0.63 | 0.39 | 5.56 |
Mean (±SD) | 0.52 ± 0.08 | 0.52 ± 0.09 | 0.55 ± 0.05 | 0.61 ± 0.07 | 0.38 ± 0.07 | 5.55 ± 0.25 |
Daptomycin + exebacase | ||||||
1 | 0.55 | 0.52 | 0.56 | 0.59 | 0.18 | 0.74 |
2 | 0.32 | 0.61 | 0.52 | 0.49 | 0.16 | 0.80 |
3 | 0.67 | 0.61 | 0.63 | 0.48 | 0.18 | 0.74 |
4 | 0.49 | 0.63 | 0.59 | 0.46 | 0.19 | 0.72 |
5 | 0.47 | 0.47 | 0.64 | 0.57 | 0.21 | 0.68 |
6 | 0.60 | 0.61 | 0.57 | 0.57 | 0.24 | 0.62 |
Mean (±SD) | 0.52 ± 0.12 | 0.58 ± 0.06 | 0.59 ± 0.05 | 0.53 ± 0.06 | 0.19 ± 0.03 | 0.72 ± 0.06 |
ND, not done.