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Protein binding percentages across the study phases
| Phasea | Mean % protein binding (SD)b
|
|
|---|---|---|
| Ceftriaxone | Ertapenem | |
| 1 | 19.9 (3.7) B | 40.6 (4.2) B |
| 2 | 19.1 (6.0) C | 42.8 (3.7) C |
| 3 | 68.0 (2.3) | 68.9 (2.3) |
Phase 1, normoalbuminemia; phase 2, hypoalbuminemia; phase 3, albumin replacement.
B, significant difference (P < 0.05) between phases 1 and 3; C, significant difference (P < 0.05) between phases 2 and 3.
