FIG 4.

Predicted maximum QTc_SSB intervals after different dosing regimens, simulated from the final pharmacokinetic-pharmacodynamic model. The box plots represent the simulated maximum QTc_SSB interval, stratified by body weight, in children weighing 5 to 25 kg (data on adults are presented in Fig. S5 in the supplemental material) after receiving the old and new dosing regimen for acute malaria treatment (3-day regimen) (A) and mass drug administration (monthly 3-day regimen) (B). The dashed red lines represent an absolute QTc interval regulatory safety cutoff of 500 ms.