TABLE 2.
Resistance check for bacteriophage and antibiotics at the end of 24 h exposure
| Regimena | D712 |
MW2 |
||
|---|---|---|---|---|
| Phage resistanceb | Antibiotic resistance/elevated MIC (μg/ml) | Phage resistanceb | Antibiotic resistance/elevated MIC (μg/ml) | |
| P | R | –c | R | –c |
| P-VAN | S | S | ||
| VAN | NA | NA | ||
| P-VAN-CFZ | S | S | ||
| P-VAN-CPT | S | S | ||
| P-DAP | S | S | ||
| DAP | NA | NA | ||
| P-DAP-CFZ | S | S | ||
| P-DAP-CPT | S | S | ||
| P-CFZ | S | S | ||
| P-CPT | S | S | ||
| GC | S | –c | S | –c |
a
VAN, vancomycin; DAP, daptomycin; CPT, ceftaroline; CFZ, cefazolin; P, bacteriophage Sb-1; GC, growth control.
b
Bacterial isolates were susceptible at the end of 24-h time-kill experiment. S, clear spot in double-drop method; R, resistant (phage activity was not observed within bacterial spot). Regimens not including bacteriophage were not tested for bacteriophage resistance. NA, not applicable.
c
–, antibiotic resistance/elevated MIC values were not detected. The resistance/elevated MIC test was performed against DAP, VAN, and CPT. D712 already has MIC values of >64 against CFZ.