TABLE 1.
β-Lactam MICs against clinical and laboratory-generated strains with or without variant AmpC
| Strain | AmpC variant | MIC (μg/ml)a
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CAZ | CZA | FDC | FEP | MEM | IPM | MVB | I-R | ATM | ATA | ||
| E. cloacae Ent385 | A294_P295del | >512 | 8 | >16 | 128 | 16 | 16 | 16 | 4 | >128 | 8 |
| E. coli TOP10(pAmpCEnt385) | A294_P295del | 256 | 2 | 2 | 4 | ≤0.06 | 0.5 | 0.03 | 0.25 | 16 | 0.25 |
| E. coli TOP10(pAmpCEnt385Rev) | Wild type | 128 | 0.5 | 0.5 | 0.25 | ≤0.06 | 0.5 | 0.03 | 0.25 | 16 | 0.25 |
| E. coli TOP10(pBCSK(–)) | Vector control | 0.5 | ≤0.25 | ≤0.03 | ≤0.25 | ≤0.06 | 0.25 | 0.03 | 0.25 | 0.25 | ≤0.125 |
a
CAZ, ceftazidime; CZA, ceftazidime-avibactam; FDC, cefiderocol; FEP, cefepime; MEM, meropenem; IPM, imipenem; MVB, meropenem-vaborbactam; I-R, imipenem-relebactam; ATM, aztreonam; ATA, aztreonam-avibactam.