TABLE 1.
Pharmacological actions and registration status of drugs
| Drug name | Pharmacological action | Drugs@FDA labela | WHO essential medicine statusb | Organization(s)c |
|---|---|---|---|---|
| Abemaciclib | Antineoplastic agents | NDA #208855 | NAd | USAN, INN |
| Amodiaquine dihydrochloride | Antimalarials | NDA #006441 | Essential | USP, INN, BAN |
| Anidulafungin | Antifungal agents | NDA #021948 | NA | USAN, INN, BAN |
| Bazedoxifene | Antiestrogen | NDA #22247 | NA | INN, USAN, JAN |
| Berbamine hydrochloride | Natural products | NA | NA | NA |
| Camostat | Protease inhibitor | NA | NA | JAN, INN |
| Cepharanthine | Anti-inflammatory agents | NA | NA | JAN |
| Chloroquine diphosphate | Antimalarials | ANDA #091621 | Essential | USP, BAN |
| Ciclesonide | Antiallergic agents | NDA #021658 | NA | USAN, INN |
| Clomiphene citrate | Fertility agents | ANDA #075528 | Essential | USAN, USP |
| Cyclosporine | Antifungal agents | ANDA #065017 | NA | USAN, USP |
| Digitoxin | Cardiovascular agents | ANDA #084100 | NA | USP, INN, BAN, JAN |
| Digoxin | Cardiovascular agents | NDA #021648 | Essential | USP, INN, BAN, JAN |
| Dihydrogambogic acid | Natural products | NA | NA | NA |
| Droloxifene | Antineoplastic agents | NA | NA | USAN, INN |
| Dronedarone HCl | Cardiovascular agents | ANDA #205903 | NA | USAN |
| Ebastine | Antihistaminic agents | NA | NA | USAN, INN, BAN |
| Eltrombopag | Treatment of thrombocytopenia | ANDA #209938 | NA | INN |
| Gilteritinib | Antineoplastic agents | NDA #211349 | NA | USAN, INN |
| Hexachlorophene | Anti-infective agents | NA | NA | USP, INN, BAN |
| Hydroxyprogesterone caproate | Hormones | ANDA #211777 | NA | USP, INN, JAN |
| Isoosajin | Natural products | NA | NA | NA |
| Isopomiferin | Antioxidant | NA | NA | NA |
| Ivacaftor | Treatment of cystic fibrosis | NDA #203188 | NA | USAN, INN |
| Lanatoside C | Cardiovascular agents | NA | NA | INN, BAN, DCF, JAN, NF |
| LDK378 | Antineoplastic agents | NDA #211225 | NA | USAN, INN |
| Loperamide hydrochloride | Antidiarrheals | NDA #021855 | Essential | USAN, USP, JAN |
| Lopinavir | Antiviral agents | NDA #021906 | Essential | USAN, USP, INN, BAN |
| Lusutrombopag | Treatment of thrombocytopenia | NDA #210923 | NA | USAN, INN |
| Mefloquine | Antimalarials | ANDA #076392 | Essential | USAN, INN, BAN |
| Mequitazine | Histamine antagonists | NA | NA | INN, BAN, DCF, JAN |
| Niclosamide | Antiparasitic agents | NDA #018669 | Essential | USAN, INN, BAN |
| Osajin | Natural products | NA | NA | NA |
| Osimertinib mesylate | Antineoplastic agents | NDA #208065 | NA | USAN |
| Ouabain | Cardiovascular agents | NA | NA | USP |
| Oxyclozanide | Antiparasitic agents | NA | NA | INN, BAN |
| Penfluridol | Antipsychotic | NA | NA | NA |
| Perhexiline maleate | Cardiovascular agents | NA | NA | USAN |
| Phenazopyridine hydrochloride | Analgesic | NDA #021105 | Essential | USAN, USP |
| Proscillaridin | Cardiovascular agents | NA | NA | USAN, INN, BAN, JAN |
| Quinacrine hydrochloride | Antimalarials/antiparasitic agents | NA | NA | INN, BAN |
| Remdesivir (GS-5734) | Antiviral agents | NA | NA | USAN |
| Salinomycin sodium | Antibacterial agents | NA | NA | INN, BAN |
| Tetrandrine | Antiviral agents | NA | NA | NA |
| Thioridazine hydrochloride | Antipsychotic | ANDA #088004 | NA | USP, JAN |
| Tilorone | Antiviral agents | NA | NA | INN |
| Toremifene citrate | Antineoplastic agents | ANDA #208813 | NA | USAN |
| Triparanol | Hypolipidemic agents | NA | NA | INN, BAN |
a
Latest New Drug Application (NDA) and Abbreviated New Drug Application (ANDA) information retrieved from Drugs@FDA (https://www.accessdata.fda.gov/scripts/cder/daf/; accessed March 2020).
b
According to the WHO Model List of Essential Medicines, 21st List (2019).
c
BAN, British Approved Name; DCF, Data Clarification Form; INN, International Nonproprietary Names; JAN, Japanese Accepted Name; USAN, United States Adopted Names; USP, The United States Pharmacopeial Convention; NF, USP-National Formulary.
d
NA, not available.