Table 3.

Factors that might independently correlate with change in ln‐β‐hydroxybutyrate at week 24

Factors that might independently correlate with Δln‐β‐hydroxybutyrate at week 24	Regression coefficient	P
%Δ fasting free fatty acid (increase 10%)	0.10	<0.001
%Δ HICCIR a (increase 10%)	0.04	0.02
%Δ iHOMA2%Sb (increase 10%)	0.03	<0.001
Δ ln‐TG (increase 0.1 ln[mg/dL])	−0.05	<0.001

Note: ALT, alanine aminotransferase; AST, aspartate aminotransferase; AUC, area under the curve; eGFR, estimated glomerular filtration rate; GLP‐1, glucagon‐like peptide 1; TG, triglyceride.Factors remained through stepwise variable selection with P < 0.05.Potential baseline predictors were age, sex, duration of diabetes, change in glycated haemoglobin and ln‐transformed TG from baseline to week 24 and the percentage change in the following variables from baseline to week 24: eGFR, body weight, waist circumference, fasting plasma glucose, glucose AUC_0‐120min, active GLP‐1 AUC_0‐120min, HIC_CIR, adiponectin, fasting free fatty acid, AST, ALT, ɤGTP, iHOMA2S^b and iHOMA2β^b.

^aC‐peptide AUC_0‐120min/insulin AUC_0‐120min ratio.

^bFrom the iHOMA2 model.