Figure 4.

Snake plot diagram of GPR139 agonist binding site showing 12 mutated residues in red (hot spot), green (no effect) and blue (very low expression). Drawn in GPCRdb 61 based on data from.43 N‐term: amino‐terminal, C‐term: carboxy‐terminal, ECL: extracellular loop and ICL: intracellular loop