Figure 6.

Schematic drawing of the reported GPR139 signalling in different cell types. GPR139 signalling has been reported in HEK293, CHO‐k1, COS‐1, COS‐7, SK‐N‐MC and CHO‐Trex cells. Green arrows indicate an effect on GPR139, and red horizontal T‐bars indicate inhibition of the signalling pathways by different pathway inhibitors: YM‐254890 is a G_q/11 inhibitor; Y‐27632 is a ROCK inhibitor that inhibits the G_12/13 signalling pathway; PTX, pertussis toxin, is a G_i/o inhibitor; U73122 is a PLC inhibitor, and FR900359 is a G_q/11 inhibitor. At the bottom of the drawing, the association with the different G proteins and ß‐arrestin (ß‐ARR) is given. The references are listed in light grey: Andersen et al, 201646; Dvorak et al, 201539; Hitchcock et al, 201639; Hu et al, 200937; Isberg et al, 201437; Liu et al, 201526; Matsuo et al, 200526; Nøhr et al, 2017a,35 Nøhr et al 2017b35; Nøhr et al 201942; Shehata et al, 201643; Shi et al, 201138; Süsens et al, 200638; Wang et al, 201545