Table 3.
Association with CA | Association with PRS‐S † , † | Interaction between PRS‐S and CA † , † | |||||||
---|---|---|---|---|---|---|---|---|---|
b | P‐value | 95% CI | b | P‐value | 95% CI | b | P‐value | 95% CI | |
Negative affect | 0.13 | <0.001 † , † | 0.07–0.19 | −0.02 | 0.502 | −0.08 to 0.04 | 0.07 | 0.013 † , † | 0.01–0.13 |
Positive affect | −0.12 | <0.001 † , † | −0.17 to −0.06 | 0.08 | 0.003 † , † | 0.03–0.14 | −0.05 | 0.043 | −0.10 to −0.00 |
Subtle psychosis expression | 0.18 | <0.001 † , † | 0.10–0.26 | −0.03 | 0.547 | −0.11 to 0.06 | 0.11 | 0.007 † , † | 0.03–0.19 |
CA, childhood adversity; CI, confidence interval; PRS‐S, polygenic risk score for schizophrenia.
All analyses were adjusted for age and sex.
Also adjusted for two principal components.
Significant after controlling for family‐wise type I error using the Bonferroni method (0.05/3 = 0.0167).