Table 4.

Main associations and interaction effects of CA in the models of stress‐sensitivity measures

	Association with CA			Association with PRS‐S † , †			Interaction between PRS‐S and CA † , †
	b	P‐value	95% CI	b	P‐value	95% CI	b	P‐value	95% CI
NA—Overall	0.12	<0.001*	0.07–0.18	−0.02	0.487	−0.08 to 0.04	0.07	0.012*	0.01–0.12
NA—Event	0.12	<0.001	0.07–0.18	−0.02	0.493	−0.08 to 0.04	0.07	0.013	0.01–0.12
NA—Social	0.12	<0.001	0.07–0.18	−0.02	0.473	−0.08 to 0.04	0.07	0.012	0.01–0.12
NA—Activity	0.12	<0.001	0.07–0.18	−0.02	0.471	−0.08–0.04	0.07	0.011	0.02–0.12
PA—Overall	−0.11	<0.001*	−0.16 to −0.06	0.08	0.003*	0.03–0.13	−0.05	0.042	−0.10 to −0.00
PA—Event	−0.11	<0.001	−0.16 to −0.06	0.08	0.003	0.03–0.13	−0.05	0.042	−0.10 to −0.00
PA—Social	−0.11	<0.001	−0.16 to −0.06	0.08	0.003	0.03–0.13	−0.05	0.043	−0.10 to −0.00
PA—Activity	−0.11	<0.001	−0.16 to −0.06	0.08	0.003	0.03–0.13	−0.05	0.042	−0.10 to −0.00
PE—Overall	0.18	<0.001*	0.10–0.25	−0.03	0.546	−0.11 to 0.06	0.11	0.007*	0.03–0.19
PE—Event	0.17	<0.001	0.10–0.25	−0.03	0.546	−0.11 to 0.06	0.11	0.006	0.03–0.19
PE—Social	0.18	<0.001	0.10–0.26	−0.03	0.545	−0.11 to 0.06	0.11	0.006	0.03–0.19
PE—Activity	0.18	<0.001	0.10–0.26	−0.03	0.520	−0.11 to 0.06	0.11	0.006	0.03–0.19

CA, childhood adversity; CI, confidence interval; NA, negative affect; PE, subtle psychosis expression; PA, positive affect; PRS‐S, polygenic risk score for schizophrenia.

All analyses were adjusted for age and sex.

^†Additionally adjusted for two principal components,

^*Significant after controalling for family‐wise type I error using the Bonferroni method (0.05/3 = 0.0167).