Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic diagram of the correlation of Notch signaling pathway and ER in breast cancer endocrine resistance. ER is at the center of endocrine resistance observed in breast cancer cells. Notch signaling modulates endocrine therapy through cooperating with ER in a complex network as mentioned in some sections of this review. P, phosphorylation; M, mutation; →, promotion; ⊥, inhibition; ↔, receptor ligand-binding.
