Table 2.
Linear regression with airway disease (AD) or interstitial lung disease (ILD) scores as dependent variable, and species level microbial sequencing data as independent variables, using data from 73 patients (39 CVID +IgA, 27 CVID –IgA, and 7 XLA).
| AD score | Beta | p-value | 95%CI (Beta) | R2 |
|---|---|---|---|---|
| Age | 0.057 | 0.189 | −0.005, 0.146 | |
| Gender | −0.062 | 0.966 | −2.879, 2.266 | |
| Prevotella | 0.769 | 0.027 | 0.176, 1.654 | 0.099 |
| Alloprevotella | 0.682 | 0.029 | 0.004, 1.262 | 0.097 |
| Selenomonas | 0.650 | 0.023 | 0.166, 1.168 | 0.103 |
| Megasphaera | 0.551 | 0.032 | 0.142, 1.031 | 0.095 |
| Fusobacterium | −0.704 | 0.020 | −1.252, −0.048 | 0.107 |
| Johnsonella | −1.577 | 0.035 | −2.472, −0.949 | 0.093 |
| ILD score | Beta | p-value | 95%CI (Beta) | R2 |
| Age | 0.054 | 0.562 | −0.142, 0.153 | |
| Gender | 2.180 | 0.483 | −3.581, 9.215 | |
| Streptococcus | 2.173 | 0.001 | 0.257, 4.604 | 0.176 |
| Rothia | −1.856 | 0.044 | −4.465, −0.434 | 0.082 |
Age and gender were included as covariates. Beta coefficient (beta) was bootstrapped to generate 95% confidence intervals (95%CI). Only taxa with p < 0.05 and 95% confidence intervals that do not span zero are reported.